A Multicenter Randomized Trial of Computer-driven Protocolized Weaning from Mechanical Ventilation

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A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation.

RATIONALE AND OBJECTIVES Duration of weaning from mechanical ventilation may be reduced by the use of a systematic approach. We assessed whether a closed-loop knowledge-based algorithm introduced in a ventilator to act as a computer-driven weaning protocol can improve patient outcomes as compared with usual care. METHODS AND MEASUREMENTS We conducted a multicenter randomized controlled study ...

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Protocolized versus non-protocolized weaning for reducing the duration of invasive mechanical ventilation in newborn infants.

BACKGROUND Mechanical ventilation is a life-saving intervention for critically ill newborn infants with respiratory failure admitted to a neonatal intensive care unit (NICU). Ventilating newborn infants can be challenging due to small tidal volumes, high breathing frequencies, and the use of uncuffed endotracheal tubes. Mechanical ventilation has several short-term, as well as long-term complic...

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Weaning from mechanical ventilation

D iscontinuation of ventilation is estimated to take up to 40% of the total duration of ventilatory support, and around 3–6% of patients admitted to the intensive care unit (ICU) require a prolonged course of mechanical ventilation (MV). Patients being liberated from ventilatory support therefore occupy a significantnumber of ICUbeds andhave a major impact on healthcare resources. There have be...

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Weaning from mechanical ventilation.

Approximately 20% of all mechanically ventilated patients fail their first attempt to wean. Prolonged mechanical ventilation increases morbidity, mortality, and costs. No single weaning parameter predicts patient ability to wean. Weaning studies suggest that daily trials of spontaneous breathing for appropriate patients assured by standing protocol and driven by respiratory care practitioners a...

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Weaning from mechanical ventilation.

An understanding of respiratory physiology is helpful when weaning a patient from mechanical ventilation. Various criteria are available that assess pulmonary function and the patient's ability to breathe spontaneously. The majority of patients are weaned without difficulty, but a small percentage will require careful evaluation. A complete assessment of the patient is essential during the wean...

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ژورنال

عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine

سال: 2006

ISSN: 1073-449X,1535-4970

DOI: 10.1164/rccm.200511-1780oc